0_4061 An innovative and versatile set-up for in-situ and operando measurements in an electrochemical cell is described. An original coupling between micro-Raman spectroscopy and atomic force microscopy enables one to collect data on opaque electrodes, for example crystals or organic and inorganic thin films. This system allows to correlate topographic images with spectroscopic maps during the charge exchange occurring in oxidation/reduction processes. The proposed set-up plays a crucial role when reactions, both reversible and non-reversible, are studied step by step during electrochemical reactions and/or when local chemical analysis is required.