A hallmark pathological feature of Alzheimer’s disease (AD) is aggregation and deposition of β-Amyloid peptides (Aβ) in the brain. Different complementary techniques have been applied to study the aggregation of different Aβ peptides, from monomers to fibrils, and their interaction with model membranes with biomimetic composition. Laser light scattering has been applied to investigate the early stages of Aβ peptides aggregation. Calorimetry and X-ray and neutron scattering have been used to investigate the effect of Aβ peptide interaction on the thermotropic and structural behavior of model membranes in bulk, while neutron reflectivity has been applied to study, with the Angstrom sensitivity, the structural interaction of peptides with complex membranes prepared by the Langmuir-Blodgett deposition technique . Peptide-membrane interaction was found to depend both on membrane composition and on the state of aggregation of the peptide.Moreover the N-terminal portion of Aβ was seen to interact with lipids of the bilayer probably promoting the penetration of peptide in the membrane.
 V. Rondelli, P. Brocca, S. Motta, M. Messa, L. Colombo, M. Salmona, G. Fragneto, L. Cantù, E. Del Favero, Sci. Rep. , 2016, 6, 20997.