FisMat2017 - Submission - View

Abstract's title: Removal signs of chronic pain by in vivo modulation of brain cortical sensory circuits
Submitting author: Alberto Bravin
Affiliation: European Synchrotron Radiation Facility
Affiliation Address: 71 avenue des Martyrs 38043 Grenoble Cedex
Country: France
Oral presentation/Poster (Author's request): Oral presentation
Other authors and affiliations: Antonio G. Zippo (Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate, Milan), Gloria Bertoli (Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate, Milan), Maria Pia Riccardi (Earth and Environment Department and Arvedi Laboratory, Università degli Studi di Pavia, Pavia, Italy), Veronica del Grosso, (ESRF, ID17, Rue de Martyrs, Grenoble, France), Maurizio Valente (Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate, Milan), Gian Carlo Caramenti (Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate, Milan), Paola Coan (Ludwig-Maximilians-Universität, Department of Clinical Radiology and Department of Physics, München, Germany), Gabriele E. M. Biella (Institute of Molecular Bioimaging and Physiology, Consiglio Nazionale delle Ricerche, Segrate, Milan)
Abstract

Chronic pain is a condition characterized by a wide spectrum of clinical signs and symptoms, missing a sound modelling at the neuronal network scale. We recently proposed a general theory that evidenced common electrophysiological traits in different chronic pain rat models, i.e. a collapse of relevant functional network properties, such as modularity, in the somatosensory thalamo-cortical network. Recently, theoretical considerations evidenced the fundamental role of modularity in brain evolutionary adaptative processes. In the current work, by in vivo X-ray microbeams targeting the involved somatosensory cortex, we generated cortical modules resulting in the removal of behavioral and electrophysiological signs of allodynia and hyperalgesia yet preserving normal sensory thresholds. In addition, the electrophysiological data clearly evidenced that the chronic pain collapsed talamo cortical network properties and the reduced information processing capabilities were recovered or renovated after microbeams with no significant side effects. Novel and unprecedented therapeutic appraisals for chronic pain are devised.