Chronic pain is a condition characterized by a wide spectrum of clinical signs and symptoms, missing a sound modelling at the neuronal network scale. We recently proposed a general theory that evidenced common electrophysiological traits in different chronic pain rat models, i.e. a collapse of relevant functional network properties, such as modularity, in the somatosensory thalamo-cortical network. Recently, theoretical considerations evidenced the fundamental role of modularity in brain evolutionary adaptative processes. In the current work, by in vivo X-ray microbeams targeting the involved somatosensory cortex, we generated cortical modules resulting in the removal of behavioral and electrophysiological signs of allodynia and hyperalgesia yet preserving normal sensory thresholds. In addition, the electrophysiological data clearly evidenced that the chronic pain collapsed talamo cortical network properties and the reduced information processing capabilities were recovered or renovated after microbeams with no significant side effects. Novel and unprecedented therapeutic appraisals for chronic pain are devised.