FisMat2017 - Submission - View

Abstract's title: A bifunctional graphene oxide nanohybrid for photostimulated nitric oxide release and photothermia
Submitting author: Salvatore Petralia
Affiliation: STMicroelectronics
Affiliation Address: vial stradale primosole, 50 95121 Catania Italy
Country: Italy
Oral presentation/Poster (Author's request): Poster
Other authors and affiliations: Marta Perez-Lloret (Laboratory of Photochemistry, Department of Drug Science, Viale Andrea Doria 6, 95125, Catania, Italy), Jiri Mosinger,Faculty of Science (Charles University in Prague, 2030 Hlavova, 128 43 Prague 2, Czech Republic), Sabrina Conoci (STMicroelctronics Catania Italy), Salvatore Sortino (Laboratory of Photochemistry, Department of Drug Science, Viale Andrea Doria 6, 95125, Catania, Italy)
Abstract

Graphene is an interesting material that deserves a shift of attention in the design of nanocarriers. With only one atom thick, the last carbon allotrope being discovered is a strong material and a superior conductor of heat and electricity. Oxidation of graphene results in graphene oxide (GO) a hydrophilic, and so, water-soluble biocompatible compound. The presence of hydroxyl, epoxy and carboxyl groups on its surface enables its easy functionalization. Because its small size, low cost, high loading capacity, solubility in water, large surface, biocompatibility, optical proprieties, GO is a perfect candidate to treat several diseases, specially in the very promising fields of photothermal and photodynamic therapies (PTT and PDT).

Nitric oxide (NO) is a double edged-sword, which can have beneficial or deleterious effect, depending on the concentration. This short half live radical presenting reduced distance diffusion in cellular environment does not suffer multidrug resistance (MDR). We report herein a GO covalently bonded with a nitroaniline derivative nitric oxide photodonor [1] resulting in a bimodal nanoplatform that combine light-controlled NO release with photothermal proprieties, having intriguing prospect in nanomedicine.

 

References  

[1] E. B. Caruso, S. Petralia, S. Conoci, S. Giuffrida and S. Sortino, J. Am. Chem. Soc., 2007, 129, 480; S. Conoci, S. Petralia and S. Sortino, 2006, EP2051935A1/US20090191284.

 

 

 

 

 

 

phene is an interesting material that deserves a shift of attention in the design of nanocarriers. With only one atom thick, the last carbon allotrope being discovered is a strong material and a superior conductor of heat and electricity. Oxidation of graphene results in graphene oxide (GO) a hydrophilic, and so, water-soluble biocompatible compound. The presence of hydroxyl, epoxy and carboxyl groups on its surface enables its easy functionalization. Because its small size, low cost, high loading capacity, solubility in water, large surface, biocompatibility, optical proprieties, GO is a perfect candidate to treat several diseases, specially in the very promising fields of photothermal and photodynamic therapies (PTT and PDT).

Nitric oxide (NO) is a double edged-sword, which can have beneficial or deleterious effect, depending on the concentration. This short half live radical presenting reduced distance diffusion in cellular environment does not suffer multidrug resistance (MDR). We report herein a GO covalently bonded with a nitroaniline derivative nitric oxide photodonor [1] resulting in a bimodal nanoplatform that combine light-controlled NO release with photothermal proprieties, having intriguing prospect in nanomedicine