Free radicals and in particular reactive oxygen species (ROS) are on the basis of several lethal and debilitating inflammatory pathologies like cardiovascular and neurodegenerative disease, ageing and cancer. Understanding their role in the disease progressions and ability to control the redox mechanisms of diseased cells via ROS insults might thus open important perspectives for health-protection strategies and therapeutic interventions1,2
The melanins, due to their natural antioxidant systems based on phenolic building blocks and to their hierarchical organizations and supramolecular architectures, can represent a possible problem-solving strategies, as they can ensuring functional efficiency and ability to respond dynamically to stimuli, bio-compatibility and suitable flexibility for integration with biological tissues and organs.
The mussel-inspired adhesive, polydopamine 3,4 was largely investigated for a broad range of biomedical applications, such as free radical inhibition, surface functionalization and coating, and recently in drug delivery 5-8 due to the possible exploitation of their tunable redox behavior associated with the various oxygenation patterns, providing an intriguing source of inspiration for efficient antioxidant and free radical scavengers for control and prevention of oxidative stress.9
Poliydopamine nanoparticles (pDA NPs) can be envisaged as a promising multifunctional and safe nanovectors for cancer therapy because of the high physiological stability and response to environmental pH and redox state, basic requirements for cell uptake and treatments
This work show results on redox activity modulation by adopting an alternative route for pDA nanoparticle (pDA NPs) obtained by pDA disassembling in ionic liquid (IL). This method was proven to expand the strategies adopted for pDA NPs surface functionalization. The estimate of pDA nanofragments dimension provided by SEM and TEM analysis returned a mean pDA fragment diameter not higher than 50nm.9 Interestingly, impedance spectroscopy (EIS) and NMR results evidenced that the resulting redox activity is a joint process determined both by the ionic liquid and the pDA NPs surface chemical functionalization. It follows that the elicited pDA -NPs surface engineering method can be trusted as an interesting green method for expanding the possible recipes for pDA NPs insertion as a tools in drug delivery and theranostics.
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