Genova has two main railway stations. Genova Piazza Principe ( center-west) is the main departure/arrival point to and from the North and West (directions Milan, Turin, Switzerland, France). Genova Brignole (center-east) is the main departure/arrival point for connections to the south (direction Pisa-Rome).
Genova is connected to the national network by four motorways
A7 Milano - Genova (GE Ovest exit).
A10 Ventimiglia (Nice) - Genova (GE Ovest exit)
A12 Livorno - Genova (GE Nervi exit)
A26 Gravellona (Simplon) - Genova : (junction to A10 at GE Voltri and then GE Ovest exit)
Remember that Genova is one of the largest port in the Mediterranean. Genova is connected by ferry lines with Barcelona, Tunis and Tangier and, obviosuly with Sardinia, Corsica (Corse) and Sicily.